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Rhubarb is well known for aggravating arthritis, rhematism, gout, epilepsy, kidney stones & various other health problems associated with uric acid.If you have any of the above health problems then it would be best to limit how much rhubarb you eat or avoid it altogether.
Here's a bit of the scientific stuff, it makes interesting reading:http://www.rhubarbinfo.com/rhubarb-poison.html
GULP! :o I never knew it could be so harmful! Mind you, it brings a new meaning to a murder weapon if you were killed by a rhubarb crumble! ;D
Oxalic acid from the rhubarb gets into the bloodstream, and reacts with calcium there, producing a fine precipitate of calcium oxaltate, which then clogs up the kidneys. I handle the stuff so I checked! Presumably it interacts with uric acid somehow as well.(from Amphibian)I test Oxalate levels in people's urine, as part of a Metabolic Stone Profile, Calcium Oxalate is a significant factor in kidney stone formation. Being a non-soluble crystal it is hard for the kidneys to dispose of it.