The very first thing I run on any computer I need to work on is Malwarebytes. Get the free version (it does everything the paid version does except run continually).
http://www.malwarebytes.org/Install it, scan, Just delete everything it finds.
(My record so far is over 750 malware/junk items found on an elderly relatives computer who had let his grand children use it to play on. That computer was taking 10 minutes to boot up and 5 mins to load a web pages.)
Also, use a program like
Autoruns (also free)
http://technet.microsoft.com/en-us/sysinternals/bb963902.aspxIts a tiny program, run it, and under the 'logon' tab, theres a list of the programs that try to run when you boot up. Chances are its pretty full. At very most you might actually need 4 or 5 things. The important ones to have running are your firewall and antivirus - uncheck the rest and reboot.